Delayed Therapy with Plasma Gelsolin Improves Survival in Murine Pneumococcal Pneumonia
نویسندگان
چکیده
1517. ZTI-01 Treatment Improves Survival of Animals Infected with Multidrug Resistant Pseudomonas aeruginosa Matthew B Lawrenz, PhD; Ashley Eb denDekker, BS, RLAT, LVT; Daniel E Cramer, PhD; Jon D Gabbard, PhD; Kathryn M Lafoe, BS, RALAT; Tia L Pfeffer, BA; Julie B Sotsky, PhD; Carol D Vanover, RLAT; Evelyn J. Ellis-Grosse, PhD and Jonathan M Warawa, PhD; Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, Kentucky, Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville School of Medicine, Louisville, Kentucky, Zavante Therapeutics, Inc., San Diego, California
منابع مشابه
Plasma gelsolin improves lung host defense against pneumonia by enhancing macrophage NOS3 function.
Plasma gelsolin (pGSN) functions as part of the "extracellular actin-scavenging system," but its potential to improve host defense against infection has not been studied. In a mouse model of primary pneumococcal pneumonia, recombinant human pGSN (rhu-pGSN) caused enhanced bacterial clearance, reduced acute inflammation, and improved survival. In vitro, rhu-pGSN rapidly improved lung macrophage ...
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عنوان ژورنال:
دوره 4 شماره
صفحات -
تاریخ انتشار 2017